||Neonatal Drug Therapy Manual
Cyclopentolate/Phenylephrine (Special Access Program)
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
- To produce a mydriasis of the eye, prior to examination
- To minimize systemic absorption, apply finger pressure on the lacrimal sac for 1 - 2 minutes following instillations
- Instill 1 drop Q5 minutes x 3 doses at time ordered by MD
- CVS: tachycardia, hypertension
- GI: feeding intolerance
- Local: transient stinging
- Ocular: elevated intraoccular pressure, photophobia
Reconstitution and Stability:
Each mL contains:
Cyclopentolate hydrochloride 2 mg
Phenylephrine hydrochloride 10 mg
Preserved with 0.01% benzalkonium chloride
Oskan Derinoz, Hamdi C Emeksiz. Use of phystostigmine for cyclopentolate overdose in an infant. Pediatrics 2012; 130 e 703. August 20, 2012
Ayse Buyukcam, H. Tolga Celik, Korkmaz Ayse etal. Myoclonic seizure due to cyclopentolate eye drop in a pre term infant. The Turkish Journal of Pediatrics. 2012;54:419-20
Fitzgerald DA, Hanson RM, West C et al. Seizures associated with 1% cyclopentolate eye drops. J pediatric Child Health. 1990 April; 26 (2): 106-7
Systemic Toxicity of topical cyclopentolate eye drops in a child. Eye (2012) 26, 1391-1392: July 2012
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