Neonatal Drug Therapy Manual

Succinylcholine

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Anectin, Quelicin
Classification: 
Skeletal Muscle Relaxant
Original Date: 
June 1996
Revised Date: 
August 2011
Indications: 
  • For endotracheal intubation
Administration: 
  • IV Direct
  • IM only if no intravenous access
Dosage: 
  • IV: 1 - 2 mg/kg (0.05 - 0.1 mL/kg) then 0.3 - 0.6 mg/kg/dose Q5-10min PRN
  • IM: 4 mg/kg/dose (0.2 mL/kg)
Side Effects: 
  • CVS: bradycardia, hypotension
  • GI: excessive salivation

  • Respiratory: respiratory muscle paralysis, risk of pulmonary aspiration because of lack of airway protection
Parameters to Monitor: 
  • BP, HR
  • Ventilation, oxygen saturation
Reconstitution and Stability: 
  • Unopened vials are stable for 6 months at room temperature without significant loss of potency
Compatibility: 

- Solutions Compatible: dextrose up to D10W, saline solutions, dextrose-saline solutions

Incompatible: alkaline solution, sodium bicarbonate

Notes: 
  • Muscle relaxation effects last about 2 - 4 minutes
  • Effects are not reversible with neostigmine or endrophonium
References: 

Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 9th-11th Editions. Hudson: Lexi-Comp Inc.; 2002-2004.

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