Neonatal Drug Therapy Manual

Amoxicillin and Clavulanic Acid

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Original Date: 
February 2010
  • Infection due to susceptible organisms
  • Prophylaxis of urinary tract infections in patients awaiting VCUG
  • PO: administer at the start of the feed
  • Treatment: 30 mg/kg/day (of amoxicillin component) divided Q12H
  • Prophylaxis: 15 mg/kg/day (of amoxicillin component) once daily
Side Effects: 
  • GI: nausea, vomiting, diarrhea
  • Hematologic: transient neutropenia, thrombocytopenia, anemia
  • Hepatic: liver enzymes elevated
Parameters to Monitor: 
  • With prolonged therapy, monitor renal, hepatic and hematologic functions periodically
Reconstitution and Stability: 




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