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Neonatal Drug Therapy Manual |
Amoxicillin and Clavulanic Acid
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Indications:
- Infection due to susceptible organisms
- Prophylaxis of urinary tract infections in patients awaiting VCUG
Administration:
- PO: administer at the start of the feed
Dosage:
- Treatment: 30 mg/kg/day (of amoxicillin component) divided Q12H
- Prophylaxis: 15 mg/kg/day (of amoxicillin component) once daily
Side Effects:
- GI: nausea, vomiting, diarrhea
- Hematologic: transient neutropenia, thrombocytopenia, anemia
- Hepatic: liver enzymes elevated
Parameters to Monitor:
- With prolonged therapy, monitor renal, hepatic and hematologic functions periodically
Reconstitution and Stability:
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