Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Adrenergic Agonist
Original Date: 
June 1996
  • Supraventricular tachycardia (2nd line agent)
  • Treatment of hypotension
  • IV Direct: administer into a large vein to prevent the possibility of extravasation. Mix 10 mg (1 mL) in 9 mL of 0.9% NaCl, discard 9 mL and dilute the remaining 1 mL with 9 mL of 0.9% NaCl for a final concentration of 100 mcg/mL. Administer desired dose over 20-30 seconds
  • IV continuous infusion
  • IM, SC
  • Hypotension/Shock:
    • IV Direct: 5-20 mcg/kg/dose Q10-15 min PRN
    • IV continuous infusion: 0.1-0.5 mcg/kg/min, titrate to desired effect
    • IM/SC: 100 mcg/kg/dose every 1-2 hours PRN (maximum 5000 mcg)
  • Paroxysmal Supraventricular Tachycardia:
    • IV Direct: 5-10 mcg/kg/dose over 20-30 seconds
Side Effects: 
  • CVS: hypertension, arrhythmias, reflex bradycardia
Parameters to Monitor: 
  • BP, HR
Reconstitution and Stability: 

IV Continuous infusion:

  • Phenylephrine 10 mg/mL
    • Take 1 mL (10 mg) and add to 9 mL SWFI, mix well.
    • Take 0.4 mL (0.4 mg) of the above solution and add to 19.6 mL of D5W
    • Final concentration: 20 mcg/mL

- Solutions Compatible: D5W, 0.9% NaCl, dextose-saline combinations, KCl

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