Alternate Name(s):
Phenylephrine HCL, Neosynephrine®
Classification:
Adrenergic Agonist
Original Date:
June 1996
Revised Date:
June 2024
Indications:
- Supraventricular tachycardia (2nd line agent)
- Treatment of hypotension
Administration:
- IV Direct: administer into a large vein to prevent the possibility of extravasation, using 100 mcg/mL dilution. Administer desired dose over 20-30 seconds
- IV continuous infusion
- IM, SC
Dosage:
- Hypotension/Shock:
- IV Direct: 5-20 mcg/kg/dose Q10-15 min PRN
- IV continuous infusion: 0.1-0.5 mcg/kg/min, titrate to desired effect
- IM/SC: 100 mcg/kg/dose every 1-2 hours PRN (maximum 5000 mcg)
- Paroxysmal Supraventricular Tachycardia:
- IV Direct: 5-10 mcg/kg/dose over 20-30 seconds
Side Effects:
- CVS: hypertension, arrhythmias, reflex bradycardia
Parameters to Monitor:
- BP, HR
Reconstitution and Stability:
IV Direct:
- Phenylephrine 10 mg/mL
- Mix 10 mg (1 mL) in 9 mL of SWFI, mix well.
- Take 1 mL (1 mg) of the above solution and dilute with with 9 mL of 0.9% NaCl or D5W
- Final concentration: 100 mcg/mL
IV Continuous infusion:
- Phenylephrine 10 mg/mL
- Take 1 mL (10 mg) and add to 9 mL SWFI, mix well.
- Take 0.4 mL (0.4 mg) of the above solution and add to 19.6 mL of D5W
- Final concentration: 20 mcg/mL
- Phenylephrine 10 mg/mL
- Take 1 mL (10 mg) and add to 9 mL SWFI, mix well.
- Take 1 mL (1 mg) of the above solution and add to 19.6 mL of D5W
- Final concentration: 50 mcg/mL
Compatibility:
- Solutions Compatible: D5W, 0.9% NaCl, dextose-saline combinations, KCl