||Neonatal Drug Therapy Manual
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Ursodeoxycholic Acid, Urso, UDCA
Gallstone Dissolution Agent; hydrophobic bile acid reducer
- Ideally taken with food
- Cholestasis treatment: 10-30 mg/kg/day divided BID-TID.
- Cholestasis prevention (from long term TPN): limited data, 20-25 mg/kg/day divided BID-QID has been used.
- GI: diarrhea/constipation, vomiting, nausea
- Rare: increased LFTs, leukopenia, thrombocytopenia, skin reactions
- Lexi-Comp Online Database, accessed May 2022
- Liu SY, Chang LW, Wang J, Xie M, Chen LL, Liu W. Ursodeoxycholic acid prevention on cholestasis associated with total parenteral nutrition in preterm infants: a randomized trial. World J Pediatr. 2022 Feb;18(2):100-108.
- Gokmen T, Oguz SS, Bozdag S, Erdeve O, Uras N, Dilmen U. A controlled trial of erythromycin and UDCA in premature infants during parenteral nutrition in minimizing feeding intolerance and liver function abnormalities. J Perinatol. 2012;32(2):123-128.
- Arslanoglu S, Moro GE, Tauschel HD, Boehm G. Ursodeoxycholic acid treatment in preterm infants: a pilot study for the prevention of cholestasis associated with total parenteral nutrition. J Pediatr Gastroenterol Nutr. 2008;46(2):228-231.
- British National Formulary for Children- 2018/19 edition.
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