Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Angiotensin-Converting Enzyme (ACE) Inhibitor
Original Date: 
August 2003
  • Treatment of congestive heart failure
  • Management of hypertension
  • PO
  • Newborns and Premature Neonates:
    • Initial: 0.01 mg/kg/dose Q8-12H
    • Titrate dose
  • Neonates:
    • Initial: 0.05 - 0.1 mg/kg/dose BID-TID
    • Titrate dose up (maintenance dose 0.3 - 6 mg/kg/day)      

Initial dose should be decreased by 50% for patients who are sodium and water depleted as a result of diuretic therapy and in patients with renal impairment.

Side Effects: 
  • CVS: hypotension, tachycardia
  • Endocrine and metabolic: hyperkalemia
  • Hematologic: neutropenia, agranulocytosis, eosinophilia
  • Renal: elevated BUN and serum creatinine
Parameters to Monitor: 
  • BP
  • Serum potassium
  • BUN and serum creatinine
  • WBC with differential
Reconstitution and Stability: 





-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 9th-11th Editions. Hudson: Lexi-Comp Inc.; 2002-2004.

-Roy R, Griffiths K, editors. The Formulary-The Hospital for Sick Children. 21st-22nd Editions. Toronto: Department of Pharmacy; 2002-2004.

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