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Neonatal Drug Therapy Manual |
Valganciclovir
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Indications:
- Treatment of congenital cytomegalovirus (CMV) disease
Side Effects:
- CVS: edema, hyper/hypotension
- Endocrine & Metabolic: dehydration, hyperglycemia, hypo/hyperkalemia, hypomagnesemia, hypophosphatemia
- GI: nausea, vomiting, diarrhea
- Hematologic: anemia, neutropenia, thrombocytopenia
- Hepatic: ascitis
- Renal: elevated urea and serum creatinine
Parameters to Monitor:
- CBC with differential, platelet count
- serum creatinine
Reconstitution and Stability:
- Prepared by pharmacy. Store oral solution in refrigerator
Notes:
- Cytotoxic drug: consult corporate policy ADM V 250 (Cytotoxic and hazardous drug waste and spills) and Nursing Policy: Cytotoxic agents and hazardous drugs: safe handling, administration and disposal
References:
- Kimberlin DW, Jester PM, Sanchez PJ, Ahmed A, Arav-Boger R, Michaels MG et al. Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease. N Engl J Med 2015; 372: 933-943
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