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Neonatal Drug Therapy Manual |
Lansoprazole
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Classification:
Gastric acid secretion inhibitor
Indications:
- Treatment of reflux esophagitis
Administration:
- PO
- Bolus feeds: administer 30 minutes before feeds
Dosage:
- < 28 days of age: 0.5 - 1.0 mg/kg/day once daily or divided Q12H
- > 28 days of age: 1.0 - 2.0 mg/kg/day once daily or divided Q12H
Side Effects:
- Dermatologic: rash
- GI: hypergastrinemia, diarrhea
- Hematologic: rare
- Hepatic: elevated serum transaminases
- Renal: proteinuria
Parameters to Monitor:
- CBC
- Liver function , liver enzymes
- Renal function
Reconstitution and Stability:
References:
-Zhang W, Kukulka M, Witt G et al. Age-dependent pharmacokinetics of lansoprazole in neonates and infants. Pardiatr Drugs.2008; 10(4): 265-74.
-Lau E. (Editor). Drug Handbook and Formulary- The Hospital for Sick Children. Toronto: 2009-2010.
-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 16th Edition. Hudson: Lexi-Comp Inc.; 2009.
-Young TE, Mangum B. Neofax®. 20th edition. Raleigh: Acorn Publishing; 2007.
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