Neonatal Drug Therapy Manual

Chloral Hydrate

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
PMS-Chloral Hydrate
Original Date: 
December 2008
Revised Date: 
  • Sedative/hypnotic prior to nonpainful therapeutic or diagnostic procedures (eg. EEG, CT scan, MRI, ophthalmic exam)
  • PO: dilute dose with water or give with feeding to reduce GI irritation
  • PR: administer oral formulation rectally as per protocol
  • Sedation pre-procedure: 25 - 50 mg/kg/dose PO/PR 30 - 60 minutes prior to procedure; may repeat a dose of 25 mg/kg 30 minutes after initial dose if needed
Side Effects: 
  • CNS: sedation, excitement (paradoxical)
  • Dermatologic: rash, urticaria
  • GI: gastric irritation, nausea, vomiting, diarrhea
  • Hematologic: leucopenia, eosinophelia
  • Respiratory: respiratory depression if combined with other sedatives or narcotics
Parameters to Monitor: 
  • Level of sedation
  • Vital signs and O2 saturation with doses used for sedation prior to procedure
Reconstitution and Stability: 





-Lau E. (Editor). Drug Handbook and Formulary- The Hospital for Sick Children. Toronto: 2008-2009.

-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 15th Edition. Hudson: Lexi-Comp Inc.; 2008.

-Esau R. (editor). British Columbias Childrens Hospital 2006-2007 Pediatrics Drug Dosage Handbook,  5th edition. Vancouver: Department of Pharmacy; 2006.


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