||Neonatal Drug Therapy Manual
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Treatment of urinary tract infections caused by susceptible strains of Gram (-) bacilli such as E. coli, Proteus mirabilis, Klebsiella pneumoniae
Prophylaxis of urinary tract infections
- PO: preferably on an empty stomach. May administer with milk if GI upset occurs
- Treatment: 4 - 6 mg/kg/day divided Q12h
- Prophylaxis: 2 - 3 mg/kg/day once daily or divided BID
Dosage adjustment required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment.
Endocrine and metabolic: hyperkalemia, hyponatremia
GI: nausea, vomiting
Hematology: megaloblastic anemia, neutropenia, thrombocytopenia
Hepatic: elevated liver enzymes, cholestatic jaundice
Renal: elevated serum creatinine and urea
Parameters to Monitor:
- CBC during long term therapy, electrolytes, liver enzymes tests, bilirubin, serum creatinine and urea
Reconstitution and Stability:
-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 9th-11th Editions. Hudson: Lexi-Comp Inc.; 2002-2004.
-Gillis C. (Editor). Compendium of Pharmaceuticals and Specialties. Ottawa: Canadian Pharmacists Association; 2002-2004.
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