Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Antihypoglycemic Agent (hormone)
Original Date: 
April 1998
Revised Date: 
December 2020
  • Hypoglycemia
  • IV direct: over 1 - 5 minutes undiluted
  • IV continuous infusion
  • SC
  • IM


  • Although GlucaGen (Novo Nordisk) is not approved by Health Canada for IV or SC administration, there is strong documentation in the literature supporting its efficacy and safety by these routes.
  • IV direct, SC, IM:  
    • 0.03 mg/kg/dose (Maximum: 0.5 mg/dose)
    • May repeat prn
    • rise in glucose may last about 2 hours, typically between 30 minutes to 2 hours
  • IV continuous infusion:
    • Initial dose: 1 - 1.5 mg/day
    • Maintenance dose: 0.1 - 1.5 mg/day
Side Effects: 
  • CVS: hypotension
  • Endocrine and metabolic: hypocalcemia, hypokalemia, rebound hypoglycemia
  • GI: nausea and vomiting
  • Miscellaneous: hypersensitivity reactions
Parameters to Monitor: 
  • BP
  • Blood glucose
  • Serum electrolytes
Reconstitution and Stability: 
  • IV direct, SC, IM:
    • Glucagon 1 mg vial
      • Reconstitute content of vial with 1 mL of the diluent provided 
      • Final concentration: 1 mg/mL
  • IV continuous infusion:
    • Glucagon 1 mg vial
      • Reconstitute content of vial with 1 mL of the diluent provided
      • Take 1 mL (1 mg) and add to 23 mL of D10W
      • Final concentration: 0.04 mg/mL

- Solutions Compatible: D5W, D10W


- Incompatible: 0.9% NaCl (including flushes)

  • 1 mg  =  1 unit

- Thornton S, Stanley C, De Leon D, Harris D, Haymond M, Hussain K, et al. Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children. The Journal of Pediatrics. 2015, Vol 167, No 2, 238-244


The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

Reliance on any information in this website is at the user's own risk. CHEO is not responsible or liable for any harm, loss or other consequences from the use or misuse of the information on this website.