Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
RSV Immune Globulin, Synagis
Humanized Monoclonal Antibody
Original Date: 
December 1998
  • Prevention of serious lower respiratory tract disease caused by respiratory syncytial virus (RSV) in pediatric patients at high risk of RSV, according to criteria for use
  • IM: preferably in the anterolateral aspect of the thigh. The gluteal muscle should not be used routinely as an injection site because of the risk of damage to the sciatic nerve.

*Doses greater than 1 mL should be divided.

  • 15 mg/kg/dose of body weight, every 30 days, throughout the RSV season
  • First dose will be administered within 2 weeks prior to discharge from hospital
Side Effects: 
  • Pain at injection site
  • In most studies, the incidence of adverse effects has been comparable in the placebo and palivizumab groups
Parameters to Monitor: 
  • Observe infant for a possible allergic reaction
Reconstitution and Stability: 

Palivizumab (RSV IG) 50 mg or 100 mg vial

  • To be prepared by pharmacv
  • Final concentration: 100 mg/mL

Protect from light

  • Administer within 6 hours of dilution

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