Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Original Date: 
March 1992
Revised Date: 
June 2024
  • Low dose (dopaminergic): renal vasculature dilation
  • Intermediate dose (beta): inotropic (increased heart rate)
  • High dose (alpha): vasoconstriction (increased blood pressure)
  • IV continuous infusion
  • Usual Dosing Range: 2.5-10 mcg/kg/minute; maximum 20 mcg/kg/minute
  • Titration Recommendation: Titrate by 2.5 mcg/kg/minute to maintain goal BP, Q 15 minutes1
    1 meant to be general guidance for titrations, use clinical judgment  
Side Effects: 
  • CVS: tachycardia, arrhythmia, hypo/hypertension
  • Local: thrombophlebitis (tissue sloughing/necrosis) with extravasation-treat with phentolamine 0.5 mg/mL
Parameters to Monitor: 
  • HR, BP, ECG
  • Urine output
  • Infusion site
Reconstitution and Stability: 
  • DOPamine 800 mcg/mL:
    • Withdraw 20 mL from prepared bag
    • Final concentration: 800 mcg/mL
  • DOPamine 1600 mcg/mL:
    • Withdraw 20 mL from prepared bag
    • Final Concentration: 1600 mcg/mL
  • Dopamine 3200 mcg/mL:
    • Withdraw 20 mL from prepared bag
    • Final concentration: 3200 mcg/mL (only with central line)

- Solutions Compatible: dextrose, 0.9% NaCl, dextrose-saline combinations


- Y-site Compatible: dobutamine, heparin, epinephrine, fentanyl, midazolam, milrinone, morphine, KCl (up to 40 mmol/L), SMOF, TPN


- Incompatible: acyclovir, amphotericin, ampicillin, insulin, metronidazole, sodium bicarbonate

  • Do not use if solution is brown

-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 19th Edition. Hudson: Lexi-Comp Inc.; 2012

- Trissel LA.  Handbook on Injectable Drugs. 16th Edition. Bethesda: American Society of Health-System Pharmacists; 2011

- Evidence-based Practice for Improving Quality  (EPIQ) Recommendations on Hemodynamics, 2023

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