Neonatal Drug Therapy Manual

Sodium Polystyrene Sulfonate

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Cation Exchange Resin
Original Date: 
June 1996
  • Hyperkalemia
  • PO
  • PR: Mix 1 g with 2 - 3 mL of water to make a thick suspension (not a paste). Enema should be retained for 30-60 minutes
  • 1 g/kg/dose
    • 1 gram of resin exchanges 1 mmol K
Side Effects: 
  • Endocrine and metabolic: hypokalemia, hypocalcemia, hypomagnesemia, hypernatremia
  • GI: nausea, vomiting, constipation
Parameters to Monitor: 
  • Serum electrolytes


Reconstitution and Stability: 


  • Compatible with: sorbitol, water, D5W
  • Each gram of resin contains 4.1 mmol of Na

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