Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Dalacin C
Original Date: 
March 1992
Revised Date: 
April 2017
  • Treatment of infections due to anaerobic bacteria and some Staphylococci
  • IV intermittent infusion: over 15 - 30 minutes

< 1.2 kg:

  • 0 - 4 weeks: 10 mg/kg/day divided Q12H

1.2 - 2 kg:

  • 0 - 7 days: 10 mg/kg/day divided Q12H
  • > 7 days: 15 mg/kg/day divided Q8H

>  2 kg :

  • 0 - 7 days: 15 mg/kg/day divided Q8H
  • > 7 days: 20 mg/kg/day divided Q6H
  • Reduce dosage in patients with severe renal or hepatic impairment.  Refer to available references or clinical pharmacist for dosage adjustment
Side Effects: 
  • GI: pseudomembranous colitis (due to Clostridium difficile overgrowth)-characterized by bloody diarrhea, abdominal pain- treat with metronidazole or oral vancomycin
Parameters to Monitor: 
  • Observe for changes in bowel frequency and stools, abdominal tenderness
Reconstitution and Stability: 


  • Clindamycin 150 mg/mL
    • Take 2 mL (300 mg) and add to 23 mL D5W or 0.9%NaCl
    • Final concentration: 12 mg/mL


  • Clindamycin 150 mg/mL
    • Take 1 mL (150 mg) and add to 24 mL D5W
    • Final concentration: 6 mg/mL

- Solutions Compatible: D5W, D10W, 0.9% NaCl, dextrose-saline combinations

- Y-site Compatible: acyclovir, gentamicin, heparin, hydromorphone, midazolam, milrinone, morphine, TPN

Incompatible: azithromycin, caspofungin, fluconazole, pantoprazole


-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 22nd Edition. Hudson: Lexi-Comp Inc.; 2015.

-American Society on Health-System Pharmacists (ASHP). Handbook on Injectable Drugs. 19th Edition. Bethesda: American Society of Health-System Pharmacists; 2017

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