Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Carbonic anhydrase inhibitor
Original Date: 
June 1996
Revised Date: 
March 2018
  • To reduce the rate of cerebrospinal fluid production in hydrocephalus
  • Treatment of metabolic alkalosis
  • PO
  • 25 mg/kg/day divided Q6H. Increase as needed by 25 mg/kg/day, to a maximum of 100 mg/kg/day divided Q6H


  • Metabolic alkalosis:
    • 5 mg/kg/dose every 6 to 8 hours
Side Effects: 
  • Endocrine and metabolic: hypokalemia, metabolic acidosis
  • Respiratory: hyperpnea
Parameters to Monitor: 
  • Head circumference
  • Serum electrolytes, serum bicarbonate
  • Acid-base balance
Reconstitution and Stability: 





Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 22nd Edition. Hudson: Lexi-Comp Inc.; 2015.

Andrews MG, Johnson PN, Lammers EM, Harrison DL, Miller JL. Acetazolamide in critically ill neonates and children with metabolic alkalosis. Ann Pharmacother. 2013;47(9):1130-1135.

Tam B, Chhay A, Yen L, Tesoriero L, Ramanathan R, Seri I, Friedlich PS. Acetazolamide for the management of chronic metabolic alkalosis in neonates and infants. Am J Ther. 2014;21(6):477-481

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