Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Hydrochlorothiazide and Spironolactone
Thiazide and Potassium Sparing diuretic
Original Date: 
June 1996
Revised Date: 
February 2023
  • Edema, hypertension
  • May improve lung function in BPD patients.
  • PO
  • 2 - 4 mg/kg/day divided in 2 doses
Side Effects: 
  • Endocrine and metabolic: electrolyte abnormalities, hyperglycemia
  • Renal: hyperuricemia
Parameters to Monitor: 
  • Serum electrolytes
  • Blood glucose
  • Signs of edema
  • BP
  • Urine output



Important: interaction with ACTH stim test

  • the spironolactone component of Aldactazide might falsely elevate plasma cortisol levels, which can impair the accuracy of diagnosis when interpreting the test results. The AM dose should be held until after the test is complete
  • Young TE, Mangum B. Neofax(R). 13th-16th Editions. Raleigh: Acorn Publishing; 2000-2003.
  • Lexi-Comp Online Database, accessed Feb 2023

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