Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Hydrochlorothiazide and Spironolactone
Thiazide and Potassium Sparing diuretic
Original Date: 
June 1996
Revised Date: 
March 2022
  • Edema, hypertension
  • May improve lung function in BPD patients.
  • PO
  • 2 - 4 mg/kg/day divided in 2 doses
Side Effects: 
  • Endocrine and metabolic: electrolyte abnormalities, hyperglycemia
  • Renal: hyperuricemia
Parameters to Monitor: 
  • Serum electrolytes
  • Blood glucose
  • Signs of edema
  • BP
  • Urine output



Young TE, Mangum B. Neofax(R). 13th-16th Editions. Raleigh: Acorn Publishing; 2000-2003.

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