Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Semi-synthetic penicillin antibiotic
Original Date: 
June 1996
Revised Date: 
November 2011
  • Infections due to Gram (+) and Gram (-) aerobic cocci
  • Infections due to some Gram (+) aerobic and anaerobic bacilli
  • Prophylaxis of urinary tract infections.
  • PO
  • Neonates: 20 - 30 mg/kg/day divided Q12H
  • Infants: (corrected GA > 42 weeks and PNA > 4 weeks): 50 mg/kg/day divided Q8H
  • UTI prophylaxis (hydronephrosis, vesicoureteral reflux):
    • 10 - 15 mg/kg/day once daily
      • Due to resistance, amoxicillin should not be used for prophylaxis in infants greater than 2 months of age

Dosage adjustment required in renal impairment.  Refer to available references or clinical pharmacist for dosage adjustment.

Side Effects: 
  • Dermatologic: rash
  • GI: diarrhea
  • Hematologic anemia, neutropenia, thrombocytopenia
Parameters to Monitor: 
  • With prolonged therapy monitor renal, hepatic and hematologic functions periodically
Reconstitution and Stability: 





Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 17th Edition. Hudson: Lexi-Comp Inc.; 2010

Lau E. (Editor). Drug Handbook and Formulary - The Hospital for Sick Children.  Toronto: 2010 - 2011

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