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Neonatal Drug Therapy Manual |
Enalaprilat
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Indications:
- Treatment of neonatal hypertension
- Afterload reduction in neonates with congestive heart failure
Administration:
- IV intermittent infusion: over 5 minutes
Dosage:
- 5 - 10 mcg/kg/dose IV Q8-24H
Dosage adjustment required in renal impairment. Refer to available references or clinical pharmacist for dosage adjustment
Side Effects:
- CVS: hypotension
- Dermatologic: rash, angioedema
- Endocrine and metabolic: hypoglycemia, hyperkalemia
- Hematologic: agranulocytosis, neutropenia, anemia
- Hepatic: cholestatic jaundice
- Renal: deterioration in renal function
Parameters to Monitor:
- BP
- HR
- Renal function
- WBC
- Serum potassium
- Serum glucose
Reconstitution and Stability:
Enalaprilat 1.25 mg/mL
- Take 0.2 mL (0.25 mg) and add to 9.8 mL 0.9 % NaCl
- Final concentration: 25 mcg/mL
Compatibility:
- Solutions Compatible: D5W, 0.9% NaCl, dextrose-saline combinations
- Y-site Compatible: dopamine, fentanyl, gentamicin, heparin, KCl, morphine, penicillin, piperacillin, piperacillin-tazobactam, ranitidine, tobramycin, TPN, vancomycin
- Incompatible: amphotericin B, phenytoin
References:
-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 16th Edition. Hudson: Lexi-Comp Inc.; 2009.
-Lau E. (Editor). Drug Handbook and Formulary- The Hospital for Sick Children. Toronto: 2009-2010.
-Zenck KE, Sills JH, Koeppel RM. Neonatal Medications & Nutrition, 3rd edition. Santa Rosa, California; NICU INK Book Publishers, USA, 2003.
-Trissel LA. Handbook on Injectable Drugs. 15th Edition. Bethesda: American Society of Health-System Pharmacists 2009.
-Young TE, Mangum B. Neofax®. 20th edition. Raleigh: Acorn Publishing; 2007.
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