Neonatal Drug Therapy Manual

Isoniazid

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated January 26, 2022 - 6:00pm

Alternate Name(s): 
INH
Classification: 
Antitubercular Agent
Original Date: 
August 1997
Revised Date: 
Indications: 
  • Treatment of active tuberculosis and prevention of active tuberculosis after an exposure to active tuberculosis
Administration: 
  • PO
Dosage: 
  • 10 mg/kg/day once a day
  • Better absorbed on an empty stomach (1 hour before or 2 hours after feeds). If GI upset occurs, give with feeds
Side Effects: 
  • CNS: fever
  • GI:  loss of appetite, stomach pain, nausea and vomiting
  • Hepatic: hepatitis, 3% to 10% of children experience transient elevated liver transaminase levels
  • Neuromuscular and skeletal: peripheral neuropathy (secondary to Vitamin B6 deficiency)
Parameters to Monitor: 
  • LFTs (baseline and at least monthly)
  • Monitor for prodromal signs of hepatitis (dark urine or yellowing of eyes)
Reconstitution and Stability: 

N/A

Compatibility: 

N/A

Notes: 
  • Administer Vitamin B6 to exclusively breastfed infants
References: 

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