Neonatal Drug Therapy Manual

Isoproterenol

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated January 26, 2022 - 6:00pm

Classification: 
Inotrope
Original Date: 
March 1992
Revised Date: 
January 2014
Indications: 
  • Increase cardiac output
Administration: 
  • IV continuous infusion
Dosage: 
  • 0.05 mcg/kg/min, titrate to a maximum of 2 mcg/kg/min
Side Effects: 
  • CVS: tachycardia, cardiac arrhythmias, hypertension, hypotension
  • Endocrine and metabolic: hypokalemia, hyperglycemia, hypoglycemia
     
Parameters to Monitor: 
  • HR
  • BP
  • ECG
Reconstitution and Stability: 
  • Isoproterenol 0.2 mg/mL
    • Take 2 mL (0.4 mg) and add to 18 mL of D5W
    • Final concentration: 20 mcg/mL
Compatibility: 
  • Solutions Compatible: dextrose, 0.9% NaCl
  • Y-site Compatible: calcium, dobutamine, heparin, KCl, TPN

Incompatible: furosemide, sodium bicarbonate

References: 
  • Taketomo CK, Hodding JH, Kraus DM.  Pediatric Dosage Handbook 20thEdition. Hudson: Lexi-Comp Inc.; 2013
  • Trissel LA. Handbook on Injectable Drugs. 16thEdition. Bethesda: American Society of Health-System Pharmacists; 2011

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