Alternate Name(s):
Clavulin
Classification:
Antibiotic
Original Date:
February 2010
Revised Date:
November 2026
Indications:
- Infection due to susceptible organisms
Administration:
- PO: administer at the start of the feed
- IV
Dosage:
PO
Neonates 0-60 days PNA and weighing < 2 kg:
- No dosing recommendation available
Neonates 0-60 days PNA and weighing > 2 kg:
- 30 mg/kg/day (amoxicillin component) divided Q12H
IV
- Insufficient information for our neonate dosing guidelines; consult ID if considering for a neonate
Side Effects:
- GI: nausea, vomiting, diarrhea
- Hematologic: transient neutropenia, thrombocytopenia, anemia
- Hepatic: liver enzymes elevated
Parameters to Monitor:
- With prolonged therapy, monitor renal, hepatic and hematologic functions periodically
Reconstitution and Stability:
IV vial reconstitution:
| Vial size | Sterile water for injection | Final concentration |
| 500 mg amoxicillin/100 mg clavulanate (5:1) | 10 mL | 50 mg amoxicillin component/mL |
| 1000 mg amoxicillin/200 mg clavulanate (5:1) | 20 mL | 50 mg amoxicillin component/mL |
Further dilute reconstituted solution to 10 mg/mL:
- withdraw 4 mL from the 50 mg/mL reconstituted vial
- Add to 16 mL of NaCL 0.9%
- Final concentration: 10 mg/mL
References:
- Nelson's Neonatal Antimicrobial Therapy, 2nd edition. American Academy of Pediatrics.
- Lexi Drugs online database