Neonatal Drug Therapy Manual

Simethicone

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated January 26, 2022 - 6:00pm

Alternate Name(s): 
Ovol
Classification: 
Antiflatulent
Original Date: 
February 2009
Revised Date: 
June 2010
Indications: 
  • For relief of intestinal gas and painful symptoms of gastric bloating
Administration: 
  • PO: administer after feeds; mix with water, infant formula or other liquid
Dosage: 
  • 20 mg/dose QID
Side Effects: 
  • Usually well tolerated
Parameters to Monitor: 
  • Monitor for a decrease in symptoms such as crying, fussiness, and intestinal gas
  • Discontinue use if there is no improvement after about 48 hours
Reconstitution and Stability: 

N/A

Compatibility: 

N/A

Notes: 
  • Does not interfere with gastric secretions or nutrient absorption
References: 

-Lau E. (Editor). Drug Handbook and Formulary- The Hospital for Sick Children. Toronto: 2008-2009.

-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 15th Edition. Hudson: Lexi-Comp Inc.; 2009.

-Zenck KE, Sills JH, Koeppel RM. Neonatal Medications & Nutrition, 3rd edition. Santa Rosa, California; NICU INK Book Publishers, USA, 2003

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