Neonatal Drug Therapy Manual

Amphotericin B Lipid Complex

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Alternate Name(s): 
Original Date: 
August 2003
Revised Date: 
  • Treatment of severe systemic fungal infections and/or deep mycoses in patients:
    • who fail to respond to conventional amphotericin B
    • who develop nephrotoxicity after conventional amphotericin B
    • in whom conventional amphotericin B is contraindicated because of renal impairment
  • IV intermittent infusion: over 2 hours
  • 2.5 - 5 mg/kg/day once daily
Side Effects: 
  • CNS: fever
  • CVS: hypotension, arrhythmias
  • Endocrine and metabolic: hypokalemia, hypomagnesemia
  • Hematologic: thrombocytopenia, leukopenia, anemia
  • Renal: increased serum creatinine, renal tubular acidosis, azotemia
Parameters to Monitor: 
  • Serum creatinine, urea, urine output
  • Serum potassium and serum magnesium
  • CBC
Reconstitution and Stability: 



- Solutions Compatible: D5W

- Incompatible: Do not mix with saline-precipitation occurs.  Do not mix with other drugs

  • Less toxic than conventional amphotericin B

-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 9th-11th Editions. Hudson: Lexi-Comp Inc.; 2002-2004.

-Trissel LA. Handbook on Injectable Drugs. 12th-13th Editions. Bethesda: American Society of Health-System Pharmacists; 2003-2005.

-The Childrens Hospital of Eastern Ontario Parenteral Drug Manual. Department of Pharmacy 2003.



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