Neonatal Drug Therapy Manual

Ceftazidime

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated March 5, 2024 - 2:34pm

Alternate Name(s): 
Tazidime, Fortaz
Classification: 
Cephalosporin Antibiotic
Original Date: 
March 1993
Revised Date: 
April 2017
Indications: 
  • Severe infections due to Gram (-) organisms, including Pseudomonas
Administration: 
  • IV direct: over 3 - 5 minutes
  • IV intermittent infusion: over 15 - 30 minutes
Dosage: 

< 1.2 kg: 0 - 4 weeks: 100 mg/kg/day divided Q12H

1.2 - 2 kg:

  • 0 - 7 days: 100 mg/kg/day divided Q12H
  • > 7 days: 150 mg/kg/day divided Q8H

> 2 kg: 150 mg/kg/day divided Q8H

Side Effects: 
  • GI: diarrhea, vomiting, pseudomembranous colitis
  • Hematologic: eosinophilia, thrombocytosis, transient leukopenia, neutropenia, thrombocytopenia, lymphocytosis, positive Coombs test
  • Hepatic: transient elevation of liver enzymes
  • Local: phlebitis/inflammation at injection site
  • Renal: transient increase in serum creatinine and urea
Parameters to Monitor: 
  • Serum creatinine and urea
  • CBC
  • Injection site
Reconstitution and Stability: 

CHEO:

  • Ceftazidime 1 g vial (doses < 200 mg)
    • Add 9.4 mL SWFI to vial
    • Take 4 mL (400 mg) and add to 16 mL D5W
    • Final concentration: 20 mg/mL
  • Ceftazidime 1 g vial (doses > 200 mg)
    • Add 9.4 mL SWFI to vial
    • Final concentration: 100 mg/mL

TOH:

  • Ceftazidime 1 g vial

    • Add 9.4 mL SWFI to vial

    • Take 4 mL (400 mg) and add to 16 mL D5W

    • Final concentration: 20 mg/mL

Compatibility: 

- Solutions Compatible: D5W, D10W, 0.9% NaCl, dextrose-saline combinations

- Y-site Compatible: acyclovir, dopamine, epinephrine, famotidine, furosemide, gentamicin, heparin, hydromorphone, insulin, ketamine, milrinone, morphine, ranitidine, tobramycin, TPN

Incompatible: amiodarone,  caspofungin, dobutamine, erythromycin lactobionate, fluconazole, midazolam, pantoprazole, SMOF, vancomycin

Notes: 

Contains 2.3 mmol of sodium per gram of ceftazidime

References: 

- Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 22nd Edition. Hudson: Lexi-Comp Inc; 2015

- American Society on Health-System Pharmacists (ASHP). Handbook on Injectable Drugs. 19th Edition. Bethesda: ASHP 2017

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