Neonatal Drug Therapy Manual

Intravenous Immune Globulin (IVIG)

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Blood Product Derivative; Immune Globulin
Original Date: 
March 1992
Revised Date: 
December 2017
  • Isoimmune hemolytic disease (Rh-incompatibility)
  • Immune thrombocytopenia (ITP)
  • Administer IV slowly and titrate as tolerated over 2 hours
  • TOH: refer to protocol for administration
  • Isoimmune hemolytic disease (Rh-incompatibility):
    • 500 - 1000 mg/kg/dose IV once over 2 hours; if needed, dose may be repeated in 12 hours
    • Most effective when administered as soon as possible after diagnosis
  • Immune thrombocytopenia (ITP):
    • 400 to 1000 mg/kg/day IV for 2 to 5 consecutive days (total dose: 2000 mg/kg)
    • Maintenance dose: 400 to 1000 mg/kg/dose IV every 3 to 6 weeks based on clinical response and platelet count


Side Effects: 
  • CNS: fever
  • CVS: tachycardia, hypotension
  • Dermatologic: rash
Parameters to Monitor: 
  • HR
  • BP
Reconstitution and Stability: 
  • Obtain from Blood Bank
  • Stability is dependent upon the manufacturer and brand
  • Solution Compatible: D5W, D5W-0.2% NaCl, D15W

- Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 22nd Edition.  Hudson: Lexi-Comp Inc; 2015

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