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Neonatal Drug Therapy Manual |
Hepatitis B Immune Globulin
Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.
Indications:
- Prevention of Hepatitis B infection in newborns of mother with proven or suspected hepatitis B
Administration:
- IM: anterolateral thigh muscle
- Administer at a different site than the Hepatitis B vaccine
Dosage:
-
Infants of HbsAg+ve mothers: 0.5 mL within 12 hours of birth
-
If maternal HBV status is unknown:
-
Maternal testing should be done urgently at time of delivery
-
> 2 kg: mother's status should be determined as quickly as possible and if positive, HBIG should be given as soon as possible but within 7 days of birth
-
< 2kg: If mother's status cannot be determined within 12 hours, give HBIG within 12 hours of birth
Side Effects:
- Pain at site of injection
Reconstitution and Stability:
Notes:
- These recommendations are based on the lastest US recommendations (Redbook). Older Canadian recommendations should be updated shortly
References:
Pickering LK, ed. 2003 Red Book: Report of the Committee on Infectious Diseases, 26th ed. Elk Grove Village: American Academy of Pediatrics; 2003.
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