Neonatal Drug Therapy Manual


Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Blood Product Derivatives; Plasma Protein
Original Date: 
February 1996
Revised Date: 
December 2017
  Albumin 5% (0.05 g/mL) Albumin 25% (0.25 g/mL)
Indication Intravascular volume expansion


Protein-losing states (chylothorax, nephrotic syndrome)


0.5 - 1 g/kg/dose

(10 - 20 mL/kg/dose)

0.5 - 1 g/kg/dose

(2 - 4 mL/kg/dose)


over 30 - 60 minutes

over 2 hours

Side Effects: 
  • CVS: rapid infusion may cause vascular overload and precipitate heart failure
  • Hypersensitivity reactions may include chills, fever, nausea, urticaria
Parameters to Monitor: 
  • BP, HR
  • Temperature
Reconstitution and Stability: 



- Solutions Compatible: Dextrose (up to D10W), 0.9% NaCl

- Y-site Compatible: amino acids and dextrose

- Incompatible: Sterile water for injection, lipids, midazolam, vancomycin


  • Use within 4 hours after opening
  • Do not use if solution shows sediment

- Shalish W, et al., Uses and misuses of albumin during resuscitation and in the neonatal intensive care unit,

Seminars in Fetal & Neonatal Medicine (2017),

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