Neonatal Drug Therapy Manual

Albumin

Disclaimer: Official controlled document is the CHEO and Ottawa Hospital online copy. It is the responsibility of user to ensure that any paper copy version is the same as the online version before use.

Updated March 5, 2024 - 2:29pm

Classification: 
Blood Product Derivatives; Plasma Protein
Original Date: 
February 1996
Revised Date: 
December 2017
Indications: 
  Albumin 5% (0.05 g/mL) Albumin 25% (0.25 g/mL)
Indication Intravascular volume expansion

Anasarca

Protein-losing states (chylothorax, nephrotic syndrome)
Dose

0.5 - 1 g/kg/dose

(10 - 20 mL/kg/dose)

0.5 - 1 g/kg/dose

(2 - 4 mL/kg/dose)
Administration

over 30 - 60 minutes

over 2 hours
Side Effects: 
  • CVS: rapid infusion may cause vascular overload and precipitate heart failure
  • Hypersensitivity reactions may include chills, fever, nausea, urticaria
Parameters to Monitor: 
  • BP, HR
  • Temperature
Reconstitution and Stability: 

N/A

Compatibility: 

- Solutions Compatible: Dextrose (up to D10W), 0.9% NaCl

- Y-site Compatible: amino acids and dextrose

- Incompatible: Sterile water for injection, lipids, midazolam, vancomycin

 

Notes: 
  • Use within 4 hours after opening
  • Do not use if solution shows sediment
References: 

- Shalish W, et al., Uses and misuses of albumin during resuscitation and in the neonatal intensive care unit,

Seminars in Fetal & Neonatal Medicine (2017), http://dx.doi.org/10.1016/j.siny.2017.07.009

The information contained on this website is provided for informational purposes only, as a guide to assist physicians, nurses and other healthcare providers in deciding on the appropriate care required for a particular patient. At all times, physicians, nurses and other healthcare providers must exercise their independent clinical judgment, based on their knowledge, training and experience, taking into account the specific facts and circumstances of each patient, when deciding on the appropriate course of investigation and/or treatment to recommend in a particular clinical situation.

CHEO has made every effort to ensure that the information contained on this website is as current and accurate as possible. However, changes can occur due to ongoing research and the constant influx of new information. Where possible, hospitals and healthcare practitioners should verify the information before acting on it.

Reliance on any information in this website is at the user's own risk. CHEO is not responsible or liable for any harm, loss or other consequences from the use or misuse of the information on this website.