Alternate Name(s):
Intropin®
Classification:
Inotrope
Original Date:
March 1992
Revised Date:
June 2024
Indications:
- Low dose (dopaminergic): renal vasculature dilation
- Intermediate dose (beta): inotropic (increased heart rate)
- High dose (alpha): vasoconstriction (increased blood pressure)
Administration:
- IV continuous infusion
Dosage:
- Usual Dosing Range: 2.5-10 mcg/kg/minute; maximum 20 mcg/kg/minute
- Titration Recommendation: Titrate by 2.5 mcg/kg/minute to maintain goal BP, Q 15 minutes1
1 meant to be general guidance for titrations, use clinical judgment
Side Effects:
- CVS: tachycardia, arrhythmia, hypo/hypertension
- Local: thrombophlebitis (tissue sloughing/necrosis) with extravasation-treat with phentolamine 0.5 mg/mL
Parameters to Monitor:
- HR, BP, ECG
- Urine output
- Infusion site
Reconstitution and Stability:
- DOPamine 800 mcg/mL:
- Withdraw 20 mL from prepared bag
- Final concentration: 800 mcg/mL
- DOPamine 1600 mcg/mL:
- Withdraw 20 mL from prepared bag
- Final Concentration: 1600 mcg/mL
- Dopamine 3200 mcg/mL:
- Withdraw 20 mL from prepared bag
- Final concentration: 3200 mcg/mL (only with central line)
Compatibility:
- Solutions Compatible: dextrose, 0.9% NaCl, dextrose-saline combinations
- Y-site Compatible: dobutamine, heparin, epinephrine, fentanyl, midazolam, milrinone, morphine, KCl (up to 40 mmol/L), SMOF, TPN
- Incompatible: acyclovir, amphotericin, ampicillin, insulin, metronidazole, sodium bicarbonate
Notes:
- Do not use if solution is brown
References:
-Taketomo CK, Hodding JH, Kraus DM. Pediatric Dosage Handbook 19th Edition. Hudson: Lexi-Comp Inc.; 2012
- Trissel LA. Handbook on Injectable Drugs. 16th Edition. Bethesda: American Society of Health-System Pharmacists; 2011
- Evidence-based Practice for Improving Quality (EPIQ) Recommendations on Hemodynamics, 2023